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KMID : 1157520130090030155
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International Journal of Clinical Preventive Dentistry
2013 Volume.9 No. 3 p.155 ~ p.162
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An Animal Study on the Nano Sized Hydroxy Apatite Contained Dentifrice for Dentinal Tubule Occlusion on the Rabbit Teeth
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Cho Min-Jeong
Chun Jong-Ae
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Abstract
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Objective: The aim of this study was to evaluate dentinal tubule occlusion efficacy and safety of dentifrice containing nano sized Hydroxy Apatite for rabbit.
Methods: Subjects of this study were 15 of 14-weeks old male New Zealand white rabbits. For the study, rabbits were div-ided two groups of 7 and 14 day treatment. Upper and lower 4 incisors, totally 60 teeth were used for this experiment. Experiment dentifrice 1 and 2 are prepared by containing 2% and 8% nano sized Hydeoxy Apatite respectively. For positive control, on-sale anti-hypersensitivity dentifrice which containing 19% of micro sized Hydroxy Apatite was used. Negative control was distilled water. For the safety evaluation, microscopic observation was performed for sacrificed rabbit’s gingival tissue.
Results: 1. Experimental 1, 2 and positive control dentifrice showed dentinal tubule occlusion efficacy (p＜0.001) and 14 days treated experiment 1 and 2 groups showed higher occlusion effect than 7 days treatment (p＜0.01). 2. After 7 days treat-ment, experiment 1 and 2 dentifrice showed more effective dentinal tubule occlusion property than positive control denti-frice (p＜0.001). There is no significant difference between groups of experiment 1 and 2. 3. After 14-days treatment, denti-nal tubule occlusion efficacy was higher in orderly experiment 2, experiment 1 and positive control dentifrice (p＜0.001). 4. Any inflammation could not be found for all experimental gingival tissue samples.
Conclusion: Dentifrice containing nano-HAP showed higher dentinal tubule occlusion efficacy for rabbit than micro-HAP contained dentifrice. Dentinal tubule occlusion effect increased by nano-HAP content and treatment period. Dentifrice con-taining nano-HAP was safe for gingival tissue of rabbits.
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KEYWORD
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dentifrice, dentinal tubule, hydroxyapatite
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